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          <span class="preheader" style="color: transparent; display: none; height: 0; max-height: 0; max-width: 0; opacity: 0; overflow: hidden; mso-hide: all; visibility: hidden; width: 0;">
           PLUS: Smart toilets, explained.
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                  September 9, 2021
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                  <p style="font-size: 16px; line-height: 20px; padding-bottom: 10px; margin: 0px;">
                   Today marks the FDA’s deadline to rule on millions of applications for e-cigarette products, determining which ones are “appropriate for the protection of public health.” The fate of vaping hangs in the balance.
                  </p>
                  <p style="font-size: 16px; line-height: 20px; padding-bottom: 10px; margin: 0px;">
                   Today’s rundown:
                  </p>
                  <ul style="font-size: 16px; line-height: 20px; padding-bottom: 10px; padding-left: 12px; margin: 0;">
                   <li style="font-size: 15px; line-height: 140%; margin: 0 0 0 15px; padding: 0px;">
                    <strong>
                     Bank rules:
                    </strong>
                    Inside crypto’s banking battle.
                   </li>
                   <li style="font-size: 15px; line-height: 140%; margin: 0 0 0 15px; padding: 0px;">
                    <strong>
                     Cell-based diet:
                    </strong>
                    The future of slaughter-free meat.
                   </li>
                   <li style="font-size: 15px; line-height: 140%; margin: 0 0 0 15px; padding: 0px;">
                    <strong>
                     Holy sh*t:
                    </strong>
                    Smart toilets could save your life one day.
                   </li>
                  </ul>
                  <p style="font-size: 16px; line-height: 20px; padding-bottom: 10px; margin: 0px;">
                   Let’s do it.
                  </p>
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               The big idea
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               <h2 style="font-size: 22px; line-height: 26px; font-weight: bold; margin: 10px 0px 5px;">
                As crypto moves into the world of banking, regulators are being forced into action
               </h2>
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               <p style="font-size: 15px; line-height: 140%; margin: 5px 0px 10px;">
                BlockFi is a platform that allows customers to deposit and withdraw assets, pays interest on holdings, and lends to both individuals and institutions.
               </p>
               <p style="font-size: 15px; line-height: 140%; margin: 5px 0px 10px;">
                If that sounds like a bank to you, you’d be spot on. With a key difference from traditional financial institutions...
               </p>
               <p style="font-size: 15px; line-height: 140%; margin: 5px 0px 10px;">
                … BlockFi deals exclusively with cryptocurrencies.
               </p>
               <h4 style="font-size: 17px; height: 100%; letter-spacing: 0px; line-height: 22px; padding-top: 8px; margin: 0px;">
                <strong>
                 The firm is the poster child of crypto’s banking struggle
                </strong>
               </h4>
               <p style="font-size: 15px; line-height: 140%; margin: 5px 0px 10px;">
                Since 2017, BlockFi has amassed
                <strong>
                 $10B+
                </strong>
                in assets,
                <strong>
                 450k+
                </strong>
                retail clients, and
                <strong>
                 850
                </strong>
                employees, according to a
                <em>
                 New York Times
                </em>
                <a style="color: #d62829; text-decoration: none; -webkit-text-fill-color: #d62829;">
                 report
                </a>
                .
               </p>
               <p style="font-size: 15px; line-height: 140%; margin: 5px 0px 10px;">
                The company has also been the subject of regulatory action in
                <strong>
                 5 states
                </strong>
                claiming it’s violating securities laws.
               </p>
               <p style="font-size: 15px; line-height: 140%; margin: 5px 0px 10px;">
                Notably, BlockFi falls on the tame side of the crypto banking spectrum:
               </p>
               <ul style="font-size: 16px; line-height: 20px; padding-bottom: 10px; padding-left: 12px; margin: 0;">
                <li style="font-size: 15px; line-height: 140%; margin: 0 0 0 15px; padding: 0px;">
                 Platforms like BlockFi and Kraken are modeled after traditional banks, but without FDIC protections
                </li>
                <li style="font-size: 15px; line-height: 140%; margin: 0 0 0 15px; padding: 0px;">
                 Then there’s the Wild West of decentralized finance (AKA DeFi), where products like Compound and Aave remove humans entirely, using algorithms to enact transactions
                </li>
               </ul>
               <h4 style="font-size: 17px; height: 100%; letter-spacing: 0px; line-height: 22px; padding-top: 8px; margin: 0px;">
                <strong>
                 The rapid growth of DeFi has baffled regulators...
                </strong>
               </h4>
               <p style="font-size: 15px; line-height: 140%; margin: 5px 0px 10px;">
                … which has put new rules in flux and left crypto founders
                <a style="color: #d62829; text-decoration: none; -webkit-text-fill-color: #d62829;">
                 uncertain
                </a>
                about the legality of their products.
               </p>
               <p style="font-size: 15px; line-height: 140%; margin: 5px 0px 10px;">
                In a recent
                <a style="color: #d62829; text-decoration: none; -webkit-text-fill-color: #d62829;">
                 Twitter thread
                </a>
                , Coinbase CEO Brian Armstrong called out the SEC for sketchy behavior, citing its denial of a product that lets customers earn interest on their holdings -- a core feature of BlockFi.
               </p>
               <h4 style="font-size: 17px; height: 100%; letter-spacing: 0px; line-height: 22px; padding-top: 8px; margin: 0px;">
                <strong>
                 This uneven playing field is a product of how fast crypto is moving…
                </strong>
               </h4>
               <p style="font-size: 15px; line-height: 140%; margin: 5px 0px 10px;">
                ... and a big reason regulators are snapping into action. So far, multiple government agencies have gotten involved:
               </p>
               <ul style="font-size: 16px; line-height: 20px; padding-bottom: 10px; padding-left: 12px; margin: 0;">
                <li style="font-size: 15px; line-height: 140%; margin: 0 0 0 15px; padding: 0px;">
                 The Federal Reserve and others have initiated a “crypto sprint” to collaborate on cryptocurrency regulations
                </li>
                <li style="font-size: 15px; line-height: 140%; margin: 0 0 0 15px; padding: 0px;">
                 The SEC created a stand-alone office to focus specifically on crypto and digital assets
                </li>
               </ul>
               <p style="font-size: 15px; line-height: 140%; margin: 5px 0px 10px;">
                As money continues pouring into these products, the impact of regulator efforts could decide the fate of crypto’s unicorns, and your crypto wallet.
               </p>
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               SNIPPETS
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               <p style="font-size: 15px; line-height: 160%; margin: 0 0 0 3px; padding: 5px 0px 10px;">
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                 Just walk out:
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                Amazon is bringing its cashier-less technology to 2
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                 Whole Foods
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                stores next year. Shoppers can grab groceries and leave, with sensors tracking the goods and billing the person’s account.
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                 Apple’s miss:
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                7 years after launching
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                 Apple Pay
                </a>
                , only ~6% of users that have the service activated on their phone actually use it to pay in-store.
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                 BNPL is on fire:
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                A few weeks after Square acquired Australian “buy now, pay later” (BNPL) firm Afterpay, PayPal will buy Paidy -- a Japanese BNPL startup -- for
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                 $2.7B
                </a>
                . Also: LatAm BNPL startup Addi just raised
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                 $75m
                </a>
                .
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                <strong>
                 Lululemon is rolling
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                , with its most recent quarterly sales
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                 +63%
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                 </u>
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                YoY in the US. The $50B+ athleisure giant is on pace to reach its 2023 revenue targets by the end of this year.
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               Lab Meat
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                <img alt="lab-grown meats" src="https://inboxflows.com/_/image/https%253A%252F%252Fmedia.sailthru.com%252Fcomposer%252Fimages%252Fsailthru-prod-6ks%252Flab_grown_meat.png/?inbox_flows_img_sig=eyJwYXRoIjoiaHR0cHMlM0ElMkYlMkZtZWRpYS5zYWlsdCJ9:1mOIG7:6cdsPllYPMd2cWa1QoWlE2KDUp6XPH32QVX6f355v0E" style="height: auto; width: 100%; max-width: 600px;" width="600"/>
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             <tr>
              <td>
               <h2 style="font-size: 22px; line-height: 26px; font-weight: bold; margin: 10px 0px 5px;">
                What do you call meat if it’s grown in a lab?
               </h2>
              </td>
             </tr>
             <tr>
              <td class="h2020 ignore-defaults" style="padding: 5px 0px 0px;">
               <p style="font-size: 15px; line-height: 140%; margin: 5px 0px 10px;">
                What do you call a hamburger when the cow it came from is still alive? That’s what the Department of Agriculture (USDA) would like to know.
               </p>
               <p style="font-size: 15px; line-height: 140%; margin: 5px 0px 10px;">
                Cell-based meat -- AKA lab-grown, cultivated, or cultured meat -- scored
                <strong>
                 $360m+
                </strong>
                in funding in 2020,
                <a style="color: #d62829; text-decoration: none; -webkit-text-fill-color: #d62829;">
                 per
                </a>
                Food Dive.
               </p>
               <h4 style="font-size: 17px; height: 100%; letter-spacing: 0px; line-height: 22px; padding-top: 8px; margin: 0px;">
                <strong>
                 And it is meat
                </strong>
               </h4>
               <p style="font-size: 15px; line-height: 140%; margin: 5px 0px 10px;">
                … except it’s
                <a style="color: #d62829; text-decoration: none; -webkit-text-fill-color: #d62829;">
                 produced
                </a>
                by taking cells from animals, then cultivating them in bioreactors to grow meat in ~2-8 weeks -- no slaughter necessary.
               </p>
               <h4 style="font-size: 17px; height: 100%; letter-spacing: 0px; line-height: 22px; padding-top: 8px; margin: 0px;">
                <strong>
                 Lab-grown chicken nuggets aren’t available in the US yet
                </strong>
               </h4>
               <p style="font-size: 15px; line-height: 140%; margin: 5px 0px 10px;">
                But Singapore became the
                <a style="color: #d62829; text-decoration: none; -webkit-text-fill-color: #d62829;">
                 1st country
                </a>
                to approve cell-based meat last year, starting with nuggets from Eat Just, a California-based startup eyeing a
                <a style="color: #d62829; text-decoration: none; -webkit-text-fill-color: #d62829;">
                 $3B IPO
                </a>
                .
               </p>
               <p style="font-size: 15px; line-height: 140%; margin: 5px 0px 10px;">
                Earlier this month, the USDA
                <a style="color: #d62829; text-decoration: none; -webkit-text-fill-color: #d62829;">
                 published
                </a>
                an advance notice of proposed rulemaking asking for comments on how the department’s Food Safety and Inspection Service (FSIS) should handle labeling regulations.
               </p>
               <p style="font-size: 15px; line-height: 140%; margin: 5px 0px 10px;">
                The USDA wants input on things like customer expectations and names that could be false or misleading.
               </p>
               <h4 style="font-size: 17px; height: 100%; letter-spacing: 0px; line-height: 22px; padding-top: 8px; margin: 0px;">
                <strong>
                 And there are already differing opinions:
                </strong>
               </h4>
               <ul style="font-size: 16px; line-height: 20px; padding-bottom: 10px; padding-left: 12px; margin: 0;">
                <li style="font-size: 15px; line-height: 140%; margin: 0 0 0 15px; padding: 0px;">
                 The US Cattlemen’s Association
                 <a style="color: #d62829; text-decoration: none;">
                  thinks
                 </a>
                 only meat from slaughtered animals should be called beef or meat
                </li>
                <li style="font-size: 15px; line-height: 140%; margin: 0 0 0 15px; padding: 0px;">
                 Harvard Law School’s Animal Law and Policy Clinic is
                 <a style="color: #d62829; text-decoration: none;">
                  against
                 </a>
                 banning common terms, arguing it could be unconstitutional
                </li>
               </ul>
               <p style="font-size: 15px; line-height: 140%; margin: 5px 0px 10px;">
                Commenters have until Nov. 2 to
                <a style="color: #d62829; text-decoration: none; -webkit-text-fill-color: #d62829;">
                 weigh in
                </a>
                .
               </p>
               <p style="font-size: 15px; line-height: 140%; margin: 5px 0px 10px;">
                BTW: If you think cell-based beef is weird, a 2020 London art installation about growing steak from human cells was
                <a style="color: #d62829; text-decoration: none; -webkit-text-fill-color: #d62829;">
                 extremely controversial
                </a>
                .
               </p>
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                Business competition is
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                no matter what industry you’re in.
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              <td style="color: #D62829; font-size: 16px; font-weight: bold; letter-spacing: 1.5px; text-transform: uppercase; padding: 0px 0px 10px;">
               Toilet Tech
              </td>
             </tr>
             <tr>
              <td style="padding: 0 0 6px;">
               <a style="color: #d62829; text-decoration: none;">
                <img alt="smart toilets" src="https://inboxflows.com/_/image/https%253A%252F%252Fmedia.sailthru.com%252Fcomposer%252Fimages%252Fsailthru-prod-6ks%252Fsmart_toilets.png/?inbox_flows_img_sig=eyJwYXRoIjoiaHR0cHMlM0ElMkYlMkZtZWRpYS5zYWlsdCJ9:1mOIG7:6cdsPllYPMd2cWa1QoWlE2KDUp6XPH32QVX6f355v0E" style="height: auto; width: 100%; max-width: 600px;" width="600"/>
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              <td>
               <h2 style="font-size: 22px; line-height: 26px; font-weight: bold; margin: 10px 0px 5px;">
                Smart toilets, explained
               </h2>
              </td>
             </tr>
             <tr>
              <td class="h2020 ignore-defaults" style="padding: 5px 0px 0px;">
               <p style="font-size: 15px; line-height: 140%; margin: 5px 0px 10px;">
                In recent years, people have become very comfortable with persistent health monitoring.
               </p>
               <p style="font-size: 15px; line-height: 140%; margin: 5px 0px 10px;">
                Whether that’s an Apple Watch or a Whoop, having real-time stats on one’s vitals is big business.
               </p>
               <p style="font-size: 15px; line-height: 140%; margin: 5px 0px 10px;">
                This same consumer-focused health analysis is coming to a toilet near you, per
                <a style="color: #d62829; text-decoration: none; -webkit-text-fill-color: #d62829;">
                 <em>
                  The Wall Street Journal
                 </em>
                </a>
                .
               </p>
               <h4 style="font-size: 17px; height: 100%; letter-spacing: 0px; line-height: 22px; padding-top: 8px; margin: 0px;">
                <strong>
                 Patients regularly provide fecal and urine samples...
                </strong>
               </h4>
               <p style="font-size: 15px; line-height: 140%; margin: 5px 0px 10px;">
                … to doctors as a way to monitor gut health or identify potential diseases.
               </p>
               <p style="font-size: 15px; line-height: 140%; margin: 5px 0px 10px;">
                One example: Stanford
                <a style="color: #d62829; text-decoration: none; -webkit-text-fill-color: #d62829;">
                 researchers
                </a>
                souped up a toilet with cameras and used machine learning (ML) algorithms to study waste and urine (e.g., color, flow, volume).
               </p>
               <p style="font-size: 15px; line-height: 140%; margin: 5px 0px 10px;">
                To tell people apart, the toilet identifies individuals by their -- we promise this is a real term -- “anal print,” which are characteristics specific to their bottoms.
               </p>
               <h4 style="font-size: 17px; height: 100%; letter-spacing: 0px; line-height: 22px; padding-top: 8px; margin: 0px;">
                <strong>
                 Stanford has partnered with Korean toilet maker Izen...
                </strong>
               </h4>
               <p style="font-size: 15px; line-height: 140%; margin: 5px 0px 10px;">
                … and hopes to have a prototype ready for clinical trials by year-end.
               </p>
               <p style="font-size: 15px; line-height: 140%; margin: 5px 0px 10px;">
                Elsewhere:
               </p>
               <ul style="font-size: 16px; line-height: 20px; padding-bottom: 10px; padding-left: 12px; margin: 0;">
                <li style="font-size: 15px; line-height: 140%; margin: 0 0 0 15px; padding: 0px;">
                 <a style="color: #d62829; text-decoration: none;">
                  Duke University’s Smart Toilet Lab
                 </a>
                 has a toilet prototype that also uses camera/ML tech and extracts stool samples that can go to a lab.
                </li>
                <li style="font-size: 15px; line-height: 140%; margin: 0 0 0 15px; padding: 0px;">
                 <a style="color: #d62829; text-decoration: none;">
                  Casana
                 </a>
                 makes a toilet seat that can monitor blood pressure, heart rate, and oxygen levels.
                </li>
                <li style="font-size: 15px; line-height: 140%; margin: 0 0 0 15px; padding: 0px;">
                 <a style="color: #d62829; text-decoration: none;">
                  Medic.Life
                 </a>
                 ’s toilet gathers 20 health metrics (e.g., sugar, sodium levels) from a stool sample.
                </li>
               </ul>
               <p style="font-size: 15px; line-height: 140%; margin: 5px 0px 10px;">
                Per
                <em>
                 WSJ
                </em>
                , Google even issued a smart toilet seat patent in 2015 to monitor cardiovascular health. That’s some wild sh*t.
               </p>
              </td>
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               TRENDS
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               <center>
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                 <img src="https://inboxflows.com/_/image/https%253A%252F%252Fmedia.sailthru.com%252Fcomposer%252Fimages%252Fsailthru-prod-6ks%252Fbiohacking_market.png/?inbox_flows_img_sig=eyJwYXRoIjoiaHR0cHMlM0ElMkYlMkZtZWRpYS5zYWlsdCJ9:1mOIG7:6cdsPllYPMd2cWa1QoWlE2KDUp6XPH32QVX6f355v0E" style="width: 100%; max-width: 600px; height: auto; padding: 15px 0 0;" width="600"/>
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                <strong>
                 Shroom startups, Elon Musk, and a $54B market…
                </strong>
               </h2>
               <p style="font-size: 15px; line-height: 140%; margin: 5px 0px 10px;">
                The biohacking industry is poised for
                <em>
                 enormous growth
                </em>
                .
               </p>
               <p style="font-size: 15px; line-height: 140%; margin: 5px 0px 10px;">
                High-profile projects like Elon Musk’s Neuralink are grabbing headlines, and analysts forecast the space to grow 4.5x to become a
                <strong>
                 $54B+ industry by 2027
                </strong>
                .
               </p>
               <p style="font-size: 15px; line-height: 140%; margin: 5px 0px 10px;">
                With all of this interest and investment, there are nearly endless opportunities to get in early on the biohacking space.
               </p>
               <p style="font-size: 15px; line-height: 140%; margin: 5px 0px 10px;">
                So, our Trends team of analysts put together
                <a style="color: #d62829; text-decoration: none; -webkit-text-fill-color: #d62829;">
                 a comprehensive guide
                </a>
                on the biohacking space that breaks down the most lucrative opportunities and niches that have been overlooked.
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                 When you read through, you’ll learn:
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                <li style="font-size: 15px; line-height: 140%; margin: 0 0 0 15px; padding: 0px;">
                 How you can get in on the
                 <strong>
                  $350m in funding
                 </strong>
                 that is flowing into psychedelic startups, and how changing laws around psilocybin and microdosing could accelerate that investment
                </li>
                <li style="font-size: 15px; line-height: 140%; margin: 0 0 0 15px; padding: 0px;">
                 <strong>
                  Step-by-step strategies
                 </strong>
                 for identifying and pouncing on opportunities within the nootropic space
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                <li style="font-size: 15px; line-height: 140%; margin: 0 0 0 15px; padding: 0px;">
                 How “wearable neurotech” devices are revolutionizing the way we interact with technology and raising big funding rounds doing it
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                <li style="font-size: 15px; line-height: 140%; margin: 0 0 0 15px; padding: 0px;">
                 And much more.
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               AROUND THE WEB
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                 😴 Chill out:
                </strong>
                <a style="color: #d62829; text-decoration: none; -webkit-text-fill-color: #d62829;">
                 A Soft Murmur
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                lets you create your own white noise mixes, adding and adjusting rain, birds, singing bowls, and more.
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               <p style="font-size: 15px; line-height: 140%; margin: 5px 0px 10px;">
                <strong>
                 🤯 Wow:
                </strong>
                This
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                 optical illusion
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                works by drawing a colored grid over a black and white image. Just like that, your brain perceives the whole thing in color!
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               <p style="font-size: 15px; line-height: 140%; margin: 5px 0px 10px;">
                <strong>
                 💰How to:
                </strong>
                If you don’t have a 401(k), there are other ways to save for retirement.
                <em>
                 CNBC
                </em>
                <a style="color: #d62829; text-decoration: none; -webkit-text-fill-color: #d62829;">
                 explains
                </a>
                .
               </p>
               <p style="font-size: 15px; line-height: 140%; margin: 5px 0px 10px;">
                <strong>
                 🎸On this day:
                </strong>
                In 1956, Elvis Presley
                <a style="color: #d62829; text-decoration: none; -webkit-text-fill-color: #d62829;">
                 appeared
                </a>
                for the 1st time on “The Ed Sullivan Show.” His set included “Don’t Be Cruel” and “Love Me Tender.”
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                <strong>
                 🔨That’s interesting:
                </strong>
                3 construction workers
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                 found
                </a>
                a metal box hidden in the wall of a French mansion. Inside were 239 rare gold coins.
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               <p style="font-size: 15px; line-height: 140%; margin: 5px 0px 5px;">
                <strong>
                 🐭Haha:
                </strong>
                And now, a little rat
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                 playing
                </a>
                a little harmonica.
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                (Source: Twitter / @DougBoneparth)
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