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                  <p style="margin:0;margin-bottom:0">
                   Dear Sarah,
                  </p>
                  <p style="margin:0;margin-bottom:0">
                  </p>
                  <p style="margin:0;margin-bottom:0">
                   These days, weight loss advice can feel like a tug-of-war. Count calories, or cut carbs. Fast, or take a GLP-1. It’s one or the other. Rarely both. That kind of thinking can make the health journey feel more confusing than empowering.
                  </p>
                  <p style="margin:0;margin-bottom:0">
                  </p>
                  <p style="margin:0;margin-bottom:0">
                   But if, instead of thinking about weight loss in isolation, we think about it as part of
                   <em>
                    health
                   </em>
                   , we think differently. Health isn’t about picking sides. It’s about finding what works. It’s about finding
                   <em>
                    everything
                   </em>
                   that works, and seeing what works together. So let’s talk about that.
                  </p>
                  <p style="margin:0;margin-bottom:0">
                  </p>
                  <p style="margin:0;margin-bottom:0">
                   <strong>
                    Fasting First: Why It Still Matters
                   </strong>
                  </p>
                  <p style="margin:0;margin-bottom:0">
                  </p>
                  <p style="margin:0;margin-bottom:0">
                   When I work with patients, I almost always begin with some form of fasting. I don’t do this because it’s trendy, but because it works.
                  </p>
                  <p style="margin:0;margin-bottom:0">
                  </p>
                  <p style="margin:0;margin-bottom:0">
                   Whether you’re trying to lose weight, manage blood sugar, improve energy levels, or improve any number of other health conditions, fasting is an ideal first step. It helps reset insulin sensitivity, which plays a role in how the body stores and burns fat, produces energy, and regulates things like sleep, mood, and attention. And, when supported by a tool like Zero, fasting can be one of the easiest and most effective lifestyle interventions you can adopt.
                  </p>
                  <p style="margin:0;margin-bottom:0">
                  </p>
                  <p style="margin:0;margin-bottom:0">
                   <strong>
                    The
                   </strong>
                   <strong>
                    <em>
                     Real
                    </em>
                   </strong>
                   <strong>
                    Reason GLP-1s Can Lead to Muscle Loss
                   </strong>
                  </p>
                  <p style="margin:0;margin-bottom:0">
                  </p>
                  <p style="margin:0;margin-bottom:0">
                   GLP-1s work differently than fasting. They slow digestion, increase satiety (the feeling of fullness), and reduce appetite. Together, these things support weight loss. But they also come with some challenges. One major challenge is retaining muscle mass . . . and it’s not just because you’re not eating enough protein (although that could also be true!). It’s because of how the medication affects your insulin response.
                  </p>
                  <p style="margin:0;margin-bottom:0">
                  </p>
                  <p style="margin:0;margin-bottom:0">
                   When you eat something sugary or carb-heavy, your insulin rises. The more of it you eat, the higher your insulin rises, and the higher your insulin, the harder it is for your body to access its fat stores for fuel. GLP-1s can magnify your insulin response, meaning even if you eat just one cookie, you can end up in a high-insulin (anti-fat-burning) state. Then, because you’re not eating as much—due to slower digestion, greater satiety, and reduced appetite—your body doesn’t have other fuel available. So if it can’t reach its fat stores? It burns muscle.
                  </p>
                  <p style="margin:0;margin-bottom:0">
                  </p>
                  <p style="margin:0;margin-bottom:0">
                   <strong>
                    GLP-1s + Zero: A Smarter Way to Support Your Body
                   </strong>
                  </p>
                  <p style="margin:0;margin-bottom:0">
                  </p>
                  <p style="margin:0;margin-bottom:0">
                   The good news is that excessive muscle loss on GLP-1s doesn’t have to be inevitable. There’s a solution. And yes, it’s Zero.
                  </p>
                  <p style="margin:0;margin-bottom:0">
                  </p>
                  <p style="margin:0;margin-bottom:0">
                   When you fast with Zero, you create periods of lower insulin, which allows your body to access stored fat. When you’re also eating less, the body turns to that fat for energy. This is how GLP-1s, with the support of Zero, help you lose weight in a healthy way.
                  </p>
                  <p style="margin:0;margin-bottom:0">
                  </p>
                  <p style="margin:0;margin-bottom:0">
                   However, this doesn’t mean you should intentionally not eat for super-long periods of time while taking a GLP-1. (Then you might actually risk not eating enough protein!) The beauty of Zero is its flexibility and how it helps you become more mindful of when and what you’re eating. Simple overnight fasts with healthy, intentional fast-breakers can keep your insulin levels in check and allow for a hormone baseline reset—and they’re that much easier with Zero.
                  </p>
                  <p style="margin:0;margin-bottom:0">
                  </p>
                  <p style="margin:0;margin-bottom:0">
                   <strong>
                    A New Way Forward
                   </strong>
                  </p>
                  <p style="margin:0;margin-bottom:0">
                  </p>
                  <p style="margin:0;margin-bottom:0">
                   You don’t have to choose between fasting or medication, natural or clinical, effort or ease. You can choose one or the other—or both. You have the freedom and power to craft and adapt  a unique health journey that meets you where you are and evolves as you do.
                  </p>
                  <p style="margin:0;margin-bottom:0">
                  </p>
                  <p style="margin:0">
                   Whether you or someone you know is on a GLP-1 or you know someone who is GLP-1-curious, I encourage you to share this message. There is no health without knowledge.
                  </p>
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                  <p style="margin:0;margin-bottom:0">
                   With care,
                  </p>
                  <p style="margin:0;margin-bottom:0">
                   Dr. Naomi Parrella, MD
                  </p>
                  <p style="margin:0">
                   Chief Medical Officer at Zero Longevity Science
                  </p>
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