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width: 200px !important;
}
.column.wide,
.column.x_wide {
width: 400px !important;
}
.two-col.has-gutter .column,
.two-col.x_has-gutter .column {
max-width: 290px !important;
width: 290px !important;
}
.three-col.has-gutter .column,
.three-col.x_has-gutter .column,
.has-gutter .narrow {
max-width: 188px !important;
width: 188px !important;
}
.has-gutter .wide {
max-width: 394px !important;
width: 394px !important;
}
.two-col.has-gutter.has-border .column,
.two-col.x_has-gutter.x_has-border .column {
max-width: 292px !important;
width: 292px !important;
}
.three-col.has-gutter.has-border .column,
.three-col.x_has-gutter.x_has-border .column,
.has-gutter.has-border .narrow,
.has-gutter.x_has-border .narrow {
max-width: 190px !important;
width: 190px !important;
}
.has-gutter.has-border .wide,
.has-gutter.x_has-border .wide {
max-width: 396px !important;
width: 396px !important;
}
}
@supports (display: flex) {
@media only screen and (min-width: 620px) {
.fixed-width.has-border .layout__inner {
display: flex !important;
}
}
}
/***
* Mobile Styles
*
* 1. Overriding inline styles
*/
@media(max-width: 619px) {
.email-flexible-footer .left-aligned-footer .column,
.email-flexible-footer .center-aligned-footer,
.email-flexible-footer .right-aligned-footer .column {
max-width: 100% !important; /* [1] */
text-align: center !important; /* [1] */
width: 100% !important; /* [1] */
}
.flexible-footer-logo {
margin-left: 0px !important; /* [1] */
margin-right: 0px !important; /* [1] */
}
.email-flexible-footer .left-aligned-footer .flexible-footer__share-button__container,
.email-flexible-footer .center-aligned-footer .flexible-footer__share-button__container,
.email-flexible-footer .right-aligned-footer .flexible-footer__share-button__container {
display: inline-block;
margin-left: 5px !important; /* [1] */
margin-right: 5px !important; /* [1] */
}
.email-flexible-footer__additionalinfo--center {
text-align: center !important; /* [1] */
}
.email-flexible-footer .left-aligned-footer table,
.email-flexible-footer .center-aligned-footer table,
.email-flexible-footer .right-aligned-footer table {
display: table !important; /* [1] */
width: 100% !important; /* [1] */
}
.email-flexible-footer .footer__share-button,
.email-flexible-footer .email-footer__additional-info {
margin-left: 20px;
margin-right: 20px;
}
}
@media only screen and (-webkit-min-device-pixel-ratio: 2), only screen and (min--moz-device-pixel-ratio: 2), only screen and (-o-min-device-pixel-ratio: 2/1), only screen and (min-device-pixel-ratio: 2), only screen and (min-resolution: 192dpi), only screen and (min-resolution: 2dppx) {
.fblike {
background-image: url(https://inboxflows.com/_/image/https%253A%252F%252Fi7.cmail19.com%252Fstatic%252Feb%252Fmaster%252F13-the-blueprint-3%252Fimages%252Ffblike%25402x.png/?inbox_flows_img_sig=eyJwYXRoIjoiaHR0cHMlM0ElMkYlMkZpNy5jbWFpbDE5LiIsInRpbWUiOjE3NTMwMzM2MzUuNzg4MTgyN30:1udY83:kZNB71vYvwFk7UuN4GhxkzHy6FY4xkOXdF9NKEkrKyc) !important;
}
.tweet {
background-image: url(https://inboxflows.com/_/image/https%253A%252F%252Fi8.cmail19.com%252Fstatic%252Feb%252Fmaster%252F13-the-blueprint-3%252Fimages%252Ftweet%25402x.png/?inbox_flows_img_sig=eyJwYXRoIjoiaHR0cHMlM0ElMkYlMkZpOC5jbWFpbDE5LiIsInRpbWUiOjE3NTMwMzM2MzUuNzg4ODh9:1udY83:OOi9ksvXSjECEjOUbbT0zAICv-7j2pJb4CzuNN7CNaU) !important;
}
.linkedinshare {
background-image: url(https://inboxflows.com/_/image/https%253A%252F%252Fi9.cmail19.com%252Fstatic%252Feb%252Fmaster%252F13-the-blueprint-3%252Fimages%252Flishare%25402x.png/?inbox_flows_img_sig=eyJwYXRoIjoiaHR0cHMlM0ElMkYlMkZpOS5jbWFpbDE5LiIsInRpbWUiOjE3NTMwMzM2MzUuNzg5MTI2fQ:1udY83:JeM-RQafSPn8uDAqi6h6mmG_wBC2syrS63Hvg8s-SxQ) !important;
}
.forwardtoafriend {
background-image: url(https://inboxflows.com/_/image/https%253A%252F%252Fi10.cmail19.com%252Fstatic%252Feb%252Fmaster%252F13-the-blueprint-3%252Fimages%252Fforward%25402x.png/?inbox_flows_img_sig=eyJwYXRoIjoiaHR0cHMlM0ElMkYlMkZpMTAuY21haWwxOSIsInRpbWUiOjE3NTMwMzM2MzUuNzg5MjY4N30:1udY83:0-meUcLGFXsSQNn4Qg_I7VIBQOcxxkkBGEEVzfjwj_4) !important;
}
}
@media (max-width: 321px) {
.fixed-width.has-border .layout__inner {
border-width: 1px 0 !important;
}
.layout,
.stack .column {
min-width: 320px !important;
width: 320px !important;
}
.border {
display: none;
}
.has-gutter .border {
display: table-cell;
}
}
.cmctbl--inline table {
border-collapse: collapse;
}
</style>
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<w:WordDocument xmlns:w="urn:schemas-microsoft-com:office:word">
<w:DontUseAdvancedTypographyReadingMail/>
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<style type="text/css">
.main,.mso{background-color:#fff}.logo a:hover,.logo a:focus{color:#030304 !important}.footer-logo a:hover,.footer-logo a:focus{color:#372d1b !important}.mso .layout-has-border{border-top:1px solid #ccc;border-bottom:1px solid #ccc}.mso .layout-has-bottom-border{border-bottom:1px solid #ccc}.mso .border{background-color:#ccc}.mso h1{}.mso h1{font-size:26px !important;line-height:34px !important}.mso h2{}.mso h2{font-size:20px !important;line-height:28px !important}.mso h3{}.mso .layout__inner{}.mso .footer__share-button p{}.mso .footer__share-button p{font-family:sans-serif}
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<body class="mso">
<![endif]-->
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<body class="main no-padding" style="margin: 0;padding: 0;-webkit-text-size-adjust: 100%;">
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<table cellpadding="0" cellspacing="0" class="wrapper" role="presentation" style="border-collapse: collapse;table-layout: fixed;min-width: 320px;width: 100%;background-color: #fff;">
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<div style="border-collapse: collapse;display: table;width: 100%;">
<!--[if mso]><table align="center" class="preheader" cellpadding="0" cellspacing="0" role="presentation"><tr><td style="width: 280px" valign="top"><![endif]-->
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<div style="background-color: #000000;background: 29% 53%/cover no-repeat url(https://inboxflows.com/_/image/https%253A%252F%252Fi1.cmail19.com%252Fei%252Fd%252F18%252F4C4%252FC45%252F214458%252Fcsfinal%252FDrip-Header.jpg/?inbox_flows_img_sig=eyJwYXRoIjoiaHR0cHMlM0ElMkYlMkZpMS5jbWFpbDE5LiIsInRpbWUiOjE3NTMwMzM2MzUuNzg5NDIyfQ:1udY83:owbYXu54asRrZrIs7ctpjFUCzl5sfEYu3HbYu8FkcDY) #000000;background-position: 29% 53%;background-image: url(https://inboxflows.com/_/image/https%253A%252F%252Fi1.cmail19.com%252Fei%252Fd%252F18%252F4C4%252FC45%252F214458%252Fcsfinal%252FDrip-Header.jpg/?inbox_flows_img_sig=eyJwYXRoIjoiaHR0cHMlM0ElMkYlMkZpMS5jbWFpbDE5LiIsInRpbWUiOjE3NTMwMzM2MzUuNzg5NDIyfQ:1udY83:owbYXu54asRrZrIs7ctpjFUCzl5sfEYu3HbYu8FkcDY);background-repeat: no-repeat;background-size: cover;">
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<div class="layout one-col fixed-width stack" style="Margin: 0 auto;max-width: 600px;min-width: 320px; width: 320px;width: calc(28000% - 167400px);overflow-wrap: break-word;word-wrap: break-word;word-break: break-word;">
<div class="layout__inner" style="border-collapse: collapse;display: table;width: 100%;background-color: #ffffff;">
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<em>
<span style="text-decoration: inherit;color: #687587;">
The Gyroscope Newsletter
</span>
</em>
</p>
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<span style="text-decoration: inherit;color: #8c8b96;">
01
</span>
<span style="text-decoration: inherit;color: #e8e8e8;">
<strong>
</strong>
</span>
<span style="text-decoration: inherit;color: #9fa2bf;">
<strong>
Essay
</strong>
</span>
</p>
<p class="size-28" lang="x-size-28" style="Margin-top: 20px;Margin-bottom: 0;font-size: 24px;line-height: 32px;">
<strong>
Why Calorie Deficits "Don't Work"
</strong>
</p>
<p class="size-20" lang="x-size-20" style="Margin-top: 20px;Margin-bottom: 0;font-size: 17px;line-height: 26px;">
<em>
“I’m eating in a calorie deficit but not losing weight!”
</em>
</p>
<p style="Margin-top: 20px;Margin-bottom: 0;">
If that sounds familiar, you’re not alone.
</p>
<p style="Margin-top: 20px;Margin-bottom: 0;">
Many people diligently try to cut calories, only to find the scale stays the same.
</p>
<p style="Margin-top: 20px;Margin-bottom: 0;">
Does that mean calorie deficits don’t work?
</p>
<p style="Margin-top: 20px;Margin-bottom: 0;">
No.
</p>
<p style="Margin-top: 20px;Margin-bottom: 0;">
A
<em>
proper
</em>
calorie deficit does work for weight loss. It’s the mechanism behind every single effective weight loss diet, and simple physics and biology.
</p>
<p style="Margin-top: 20px;Margin-bottom: 20px;">
But if your deficit isn’t yielding results, chances are something is off in the way you’re implementing it. In other words, it’s not the concept of deficits that’s broken – it’s how you’re tracking or managing it.
</p>
</div>
</div>
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In this article, we’ll look at the 5 most common reasons your calorie deficit might not be “working” and how to address each one...
</p>
<p style="Margin-top: 20px;Margin-bottom: 0;">
From hidden calories that sneak into your diet to metabolic adaptations that change your needs over time, we’ll cover what might be sabotaging your progress...
</p>
<p style="Margin-top: 20px;Margin-bottom: 0;">
<strong>
<em>
And what to do about it!
</em>
</strong>
</p>
<p class="size-20" lang="x-size-20" style="Margin-top: 20px;Margin-bottom: 20px;font-size: 17px;line-height: 26px;">
You don't want to miss this one.
</p>
</div>
</div>
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<a style="border-radius: 4px;display: block;font-size: 14px;font-weight: bold;line-height: 24px;padding: 12px 24px;text-align: center;text-decoration: none !important;transition: opacity 0.1s ease-in;color: #ffffff !important;background-color: #3d63e0;font-family: sans-serif;">
Why your deficits are not working (and how to fix the issue)
</a>
<!--<![endif]-->
<!--[if mso]><p style="line-height:0;margin:0;"> </p><v:roundrect xmlns:v="urn:schemas-microsoft-com:vml" href="https://camp.gyrosco.pe/t/d-l-sudiln-yultlrktit-y/" style="width:420pt" arcsize="9%" fillcolor="#3D63E0" stroke="f"><v:textbox style="mso-fit-shape-to-text:t" inset="0pt,8.25pt,0pt,8.25pt"><center style="font-size:14px;line-height:24px;color:#FFFFFF;font-family:sans-serif;font-weight:bold;mso-line-height-rule:exactly;mso-text-raise:1.5px">Why your deficits are not working (and how to fix the issue)</center></v:textbox></v:roundrect><![endif]-->
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<span style="text-decoration: inherit;color: #8c8b96;">
02
</span>
<span style="text-decoration: inherit;color: #e8e8e8;">
<strong>
Research Review
</strong>
</span>
</p>
<p class="size-28" lang="x-size-28" style="Margin-top: 20px;Margin-bottom: 20px;font-size: 24px;line-height: 32px;">
<strong>
Can going keto help keep muscle on GLP-1 drugs?
</strong>
</p>
</div>
</div>
<div style="Margin-left: 20px;Margin-right: 20px;">
<div style="mso-line-height-rule: exactly;mso-text-raise: 11px;vertical-align: middle;">
<h2 class="size-17" lang="x-size-17" style="Margin-top: 0;Margin-bottom: 0;font-style: normal;font-weight: normal;color: #000;font-size: 17px;line-height: 26px;">
If you're using a GLP-1 drug like Ozempic, Wegovy, Mounjaro, or Zepbound, you already know how effective these medications can be for weight loss. But there's a not-so-great side effect: along with fat, you tend to lose some muscle during the weight loss process.
</h2>
<h2 class="size-17" lang="x-size-17" style="Margin-top: 16px;Margin-bottom: 0;font-style: normal;font-weight: normal;color: #000;font-size: 17px;line-height: 26px;">
In fact, studies have found that with GLP-1 drugs such as tirzepatide (Mounjaro/Zepbound), over a quarter of the weight you lose can come from lean muscle tissue – which can slow down your metabolism and even contribute to frailty.
</h2>
<h2 class="size-17" lang="x-size-17" style="Margin-top:
16px;Margin-bottom: 0;font-style: normal;font-weight: normal;color: #000;font-size: 17px;line-height: 26px;">
However, a new study suggests there may be a way to counteract this. Researchers found that pairing tirzepatide with a ketogenic diet could help preserve more lean mass and keep your metabolism stronger along the way.
</h2>
<h2 class="size-20" lang="x-size-20" style="Margin-top: 16px;Margin-bottom: 0;font-style: normal;font-weight: normal;color: #000;font-size: 17px;line-height: 26px;">
<strong>
A New Study: Tirzepatide + Keto vs. Low-Calorie Diet
</strong>
</h2>
<p class="size-17" lang="x-size-17" style="Margin-top: 16px;Margin-bottom: 0;font-size: 17px;line-height: 26px;">
A 2025 pilot study in the journal
<em>
Nutrients
</em>
followed 60 adults with overweight or obesity over 12 weeks, all of whom were on tirzepatide (the active ingredient in Mounjaro
and Zepbound).
</p>
<p class="size-17" lang="x-size-17" style="Margin-top: 20px;Margin-bottom: 0;font-size: 17px;line-height: 26px;">
The participants were split into two diet groups: half followed a standard low-calorie diet (~50% carbs), and the other half went keto – eating under 30 g of carbs per day with a higher protein intake.
</p>
<p class="size-17" lang="x-size-17" style="Margin-top: 20px;Margin-bottom: 0;font-size: 17px;line-height: 26px;">
Importantly, both diets were calorie-restricted to about 1,200 kcal/day, so any differences in outcomes could be attributed to the diet composition rather than calories alone. Here’s what happened:
</p>
<ul style="Margin-top: 20px;Margin-bottom: 20px;Margin-left: 24px;padding: 0;list-style-type: disc;">
<li style="Margin-top: 20px;Margin-bottom: 0;Margin-left: 0;">
<p class="size-17" lang="x-size-17" style="Margin-top: 0;Margin-bottom:
20px;font-size: 17px;line-height: 26px;">
<strong>
Both groups lost a similar amount of total weight.
</strong>
Roughly the same on tirzepatide whether they ate low-carb or higher-carb. In other words, tirzepatide works for weight loss regardless of diet composition.
</p>
</li>
<li style="Margin-top: 0;Margin-bottom: 0;Margin-left: 0;">
<p class="size-17" lang="x-size-17" style="Margin-top: 0;Margin-bottom: 20px;font-size: 17px;line-height: 26px;">
<strong>
The keto group lost more fat and retained more muscle
</strong>
. While both groups lost fat mass, the ketogenic diet group saw a significantly greater reduction in fat mass and minimal loss of lean mass, whereas the standard diet group lost substantially more lean mass (muscle).
</p>
</li>
<li style="Margin-top: 0;Margin-bottom: 0;Margin-left: 0;">
<p class="size-17" lang="x-size-17" style="Margin-top: 0;Margin-bottom:
20px;font-size: 17px;line-height: 26px;">
<strong>
Metabolic rate was better preserved in the keto group
</strong>
. Only the low-calorie (higher-carb) group saw a drop in their resting metabolic rate (the number of calories your body burns at rest); the keto group’s RMR held steady, suggesting they avoided the typical metabolism slowdown that often accompanies weight loss.
</p>
</li>
</ul>
</div>
</div>
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<img alt="" src="https://inboxflows.com/_/image/https%253A%252F%252Fi2.cmail19.com%252Fei%252Fd%252F18%252F4C4%252FC45%252F214458%252Fcsfinal%252FChatGPTImageJul182025at09_29_00PM-9900000000079e3c.png/?inbox_flows_img_sig=eyJwYXRoIjoiaHR0cHMlM0ElMkYlMkZpMi5jbWFpbDE5LiIsInRpbWUiOjE3NTMwMzM2MzUuODA3NzI4M30:1udY83:iVIE4C8Ro-pRQ-z3U5igxwU3_FAajoGXGnIrfV0vOY8" style="border: 0;display: block;height: auto;width: 100%;max-width: 900px;" width="600"/>
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<h2 class="size-20" lang="x-size-20" style="Margin-top: 0;Margin-bottom: 0;font-style: normal;font-weight: normal;color: #000;font-size: 17px;line-height: 26px;">
<strong>
Why Preserving Muscle Mass Matters
</strong>
</h2>
<p class="size-17" lang="x-size-17" style="Margin-top: 16px;Margin-bottom: 0;font-size: 17px;line-height: 26px;">
When you lose weight, it's not just about the number on the scale – it's about
<em>
what
</em>
you're losing. Dropping a lot of muscle along with fat can be problematic. Muscle tissue is metabolically active, so losing muscle can slow your metabolism (meaning you burn fewer calories daily) and make it easier to regain weight. It can also weaken your strength and physical function.
</p>
<p class="size-17" lang="x-size-17" style="Margin-top: 20px;Margin-bottom: 0;font-size: 17px;line-height: 26px;">
In the long run, maintaining muscle is
crucial for healthy aging; higher muscle mass and strength are associated with better mobility, metabolic health, and lower risk of frailty as you get older.
</p>
<p class="size-17" lang="x-size-17" style="Margin-top: 20px;Margin-bottom: 0;font-size: 17px;line-height: 26px;">
This is exactly why
<em>
Gyroscope’s
</em>
core message is focused on losing body fat without losing muscle. Our fat loss protocol emphasizes nutrition and training strategies to help you shed fat while preserving lean mass – keeping your metabolism humming and supporting your strength and performance throughout your weight loss journey.
</p>
<p class="size-17" lang="x-size-17" style="Margin-top: 20px;Margin-bottom: 0;font-size: 17px;line-height: 26px;">
By prioritizing adequate protein, resistance training, and smart diet choices (like lower carbs for those who tolerate it), you can maximize fat
loss and minimize muscle loss.
</p>
<h2 class="size-20" lang="x-size-20" style="Margin-top: 20px;Margin-bottom: 0;font-style: normal;font-weight: normal;color: #000;font-size: 17px;line-height: 26px;">
<strong>
Key Takeaways and Next Steps
</strong>
</h2>
<p class="size-17" lang="x-size-17" style="Margin-top: 16px;Margin-bottom: 0;font-size: 17px;line-height: 26px;">
This was a small, non-randomized pilot study, meaning people chose which diet they felt they could stick to (keto or standard low-calorie). While the results are intriguing, we should be cautious about generalizing them too broadly. The sample size was small and the trial lasted only 12 weeks, so further research is needed.
</p>
<p class="size-17" lang="x-size-17" style="Margin-top: 20px;Margin-bottom: 0;font-size: 17px;line-height: 26px;">
Larger, randomized trials will be necessary to confirm these effects and ensure
that the keto advantage for preserving muscle holds true in diverse populations.
</p>
<p class="size-17" lang="x-size-17" style="Margin-top: 20px;Margin-bottom: 0;font-size: 17px;line-height: 26px;">
That said, if you’re already on a GLP-1 medication and want to maximize fat loss while protecting your muscle, it may be worth discussing a lower-carb, higher-protein diet approach with your doctor or nutritionist. A well-formulated ketogenic diet (or generally a high-protein, reduced-carb diet) combined with these medications could potentially tilt your weight loss more toward fat and less toward muscle. Just remember that any diet should be one you can adhere to and that meets your nutritional needs.
</p>
<p class="size-17" lang="x-size-17" style="Margin-top: 20px;Margin-bottom: 20px;font-size: 17px;line-height: 26px;">
Ultimately, weight loss is great, but body recomposition
– less fat
<em>
and
</em>
more muscle – is even better. Your diet is one of the most powerful tools for influencing
<em>
what
</em>
you lose during weight loss. By choosing an eating strategy that supports muscle retention (along with staying active and getting sufficient protein), you can keep your metabolism stronger and set yourself up for better long-term health.
</p>
</div>
</div>
<div style="Margin-left: 20px;Margin-right: 20px;">
<div style="mso-line-height-rule: exactly;mso-text-raise: 11px;vertical-align: middle;">
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<p class="size-28" lang="x-size-28" style="Margin-top: 20px;Margin-bottom: 0;font-size: 24px;line-height: 32px;">
<span style="text-decoration: inherit;color: #8c8b96;">
03
</span>
<span style="text-decoration: inherit;color: #e8e8e8;">
<strong>
Study Of The Week
</strong>
</span>
</p>
<p class="size-28" lang="x-size-28" style="Margin-top: 20px;Margin-bottom: 20px;font-size: 24px;line-height: 32px;">
<strong>
Gradual vs. Fast Weight Loss
</strong>
</p>
</div>
</div>
<div style="Margin-left: 20px;Margin-right: 20px;">
<div style="mso-line-height-rule: exactly;mso-text-raise: 11px;vertical-align: middle;">
<p style="Margin-top: 0;Margin-bottom: 0;line-height: 26px;">
<em>
Every week, we will breakdown a new study to help you stay on top of the latest health and longevity developments...
</em>
</p>
<p style="Margin-top: 20px;Margin-bottom: 0;line-height: 26px;">
<em>
This week’s study is all about fast weight loss vs gradual weight loss.
</em>
</p>
<p style="Margin-top: 20px;Margin-bottom: 0;line-height: 26px;">
<em>
What is better? What does the evidence say? Read on to find out.
</em>
</p>
<p class="size-17" lang="x-size-17" style="Margin-top: 20px;Margin-bottom: 20px;font-size: 17px;line-height: 26px;">
<em>
Read the full original study
<a style="text-decoration: underline;transition: opacity 0.1s ease-in;color: #3175bf;">
<span style="text-decoration: inherit;color: #297bff;">
here
</span>
</a>
.
</em>
</p>
</div>
</div>
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<a style="text-decoration: underline;transition: opacity 0.1s ease-in;color: #3175bf;">
<img alt="" src="https://inboxflows.com/_/image/https%253A%252F%252Fi3.cmail19.com%252Fei%252Fd%252F18%252F4C4%252FC45%252F214458%252Fcsfinal%252FChatGPTImageJul182025at10_01_26PM-9900000000079e3c.png/?inbox_flows_img_sig=eyJwYXRoIjoiaHR0cHMlM0ElMkYlMkZpMy5jbWFpbDE5LiIsInRpbWUiOjE3NTMwMzM2MzUuODA3ODQ2M30:1udY83:3-Aoh_PqJvrq0kwaKu3yDU2FMOReIIM4lM8AXAIF1Kk" style="border: 0;display: block;height: auto;width: 100%;max-width: 900px;" width="600"/>
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<p class="size-20" lang="x-size-20" style="Margin-top: 0;Margin-bottom: 0;font-size: 17px;line-height: 26px;">
The purpose of this systematic review and meta-analysis was to compare the effects of gradual weight loss (GWL) versus rapid weight loss (RWL), given equivalent total weight loss, on body composition and RMR in individuals who are overweight or obese.
</p>
<p style="Margin-top: 20px;Margin-bottom: 0;">
The researchers systematically searched multiple databases, including PubMed, the Cochrane Library, Web of Science, Embase, Scopus, and Ovid, for relevant studies published up to October 2019. A fixed or random effects model was used for the meta-analysis as appropriate.
</p>
<p class="size-20" lang="x-size-20" style="Margin-top: 20px;Margin-bottom: 0;font-size: 17px;line-height: 26px;">
<strong>
Key Findings
</strong>
</p>
<p style="Margin-top: 20px;Margin-bottom: 0;">
Total Weight
Loss: The magnitude of weight loss was similar between the gradual and rapid weight loss groups, with a mean difference of 0.03 kg. Specifically, the gradual weight loss groups lost approximately 6.94 kg, while the rapid weight loss groups lost about 6.98 kg.
</p>
<p style="Margin-top: 20px;Margin-bottom: 0;">
<strong>
Fat Mass (FM) and Body Fat Percentage (BFP):
</strong>
Gradual weight loss promoted greater reductions in fat mass (mean difference of -1 kg) and body fat percentage (mean difference of -0.83%). This indicates a better preservation of lean mass with gradual weight loss.
</p>
<p style="Margin-top: 20px;Margin-bottom: 0;">
<strong>
Resting Metabolic Rate (RMR):
</strong>
Gradual weight loss significantly preserved RMR compared to rapid weight loss, showing a mean advantage of 97.3 kcal with gradual weight loss.
</p>
<p style="Margin-top: 20px;Margin-bottom: 20px;">
<strong>
Other
Measures:
</strong>
However, there were no significant differences in waist and hip circumferences, waist:hip ratio, or fat-free mass (FFM) between gradual and rapid weight loss. The source notes that the lack of difference in these parameters could be due to the similar total magnitude of weight loss achieved in the studies.
</p>
</div>
</div>
<div style="Margin-left: 20px;Margin-right: 20px;">
<div style="mso-line-height-rule: exactly;mso-text-raise: 11px;vertical-align: middle;">
<p class="size-20" lang="x-size-20" style="Margin-top: 0;Margin-bottom: 0;font-size: 17px;line-height: 26px;">
<strong>
Results and Insights
</strong>
</p>
<p style="Margin-top: 20px;Margin-bottom: 0;">
Rapid weight loss protocols typically involved 450-1500 kcal/day deficits, leading to 0.5-1.8 kg/week loss over 5-12 weeks.
</p>
<p style="Margin-top: 20px;Margin-bottom: 0;">
Gradual weight loss protocols ranged from 1200-1500 kcal/day, with deficits of 400-750 kcal/day, resulting in 0.2-1.0 kg/week loss over 9-36 weeks.
</p>
<p class="size-20" lang="x-size-20" style="Margin-top: 20px;Margin-bottom: 0;font-size: 17px;line-height: 26px;">
<strong>
The findings suggest that gradual weight loss is superior for reducing fat mass and body fat percentage, and for preserving RMR when the total weight loss amount is similar.
</strong>
</p>
<p style="Margin-top: 20px;Margin-bottom: 0;">
The absence of
resistance training and high protein intake in many of the included trials is a critical consideration. The source emphasizes that resistance training can significantly help preserve lean mass and even increase it during very-low energy diets, particularly in untrained or obese subjects. For instance, a 12-week trial found that resistance training with an 800 kcal diet preserved lean mass and increased RMR in untrained obese subjects.
</p>
<p style="Margin-top: 20px;Margin-bottom: 0;">
In lean, trained individuals, there's an elevated risk of lean mass loss if weight loss exceeds approximately 1% of total body weight per week.
</p>
<p style="Margin-top: 20px;Margin-bottom: 20px;">
This further highlights that while gradual weight loss might be generally beneficial for fat mass and RMR preservation, the inclusion of resistance training and adequate protein intake could mitigate lean mass loss
even with more aggressive caloric deficits.
</p>
</div>
</div>
<div style="Margin-left: 20px;Margin-right: 20px;">
<div style="mso-line-height-rule: exactly;mso-text-raise: 11px;vertical-align: middle;">
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</p>
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<span style="text-decoration: inherit;color: #c8c8d4;">
04
</span>
<span style="text-decoration: inherit;color: #8c8b96;">
</span>
<span style="text-decoration: inherit;">
<strong>
News Round-Up
</strong>
</span>
</p>
<p class="size-20" lang="x-size-20" style="Margin-top: 20px;Margin-bottom: 20px;font-size: 17px;line-height: 26px;">
<em>
<span style="text-decoration: inherit;">
The Latest News in Health and Artificial Intelligence
</span>
</em>
</p>
</div>
</div>
<div align="center" style="font-size: 12px;font-style: normal;font-weight: normal;line-height: 19px;">
<img alt="" src="https://inboxflows.com/_/image/https%253A%252F%252Fi4.cmail19.com%252Fei%252Fd%252F18%252F4C4%252FC45%252F214458%252Fcsfinal%252FChatGPTImageJun132025at02_04_16PM-9900000000079e3c.png/?inbox_flows_img_sig=eyJwYXRoIjoiaHR0cHMlM0ElMkYlMkZpNC5jbWFpbDE5LiIsInRpbWUiOjE3NTMwMzM2MzUuODA3OTUzOH0:1udY83:nfM45eqgcJ6-B5RMsoDc985SzDyv2LecfM4V36gmy-k" style="border: 0;display: block;height: auto;width: 100%;max-width: 900px;" width="600"/>
</div>
<div style="Margin-left: 20px;Margin-right: 20px;Margin-top: 20px;">
<div style="mso-line-height-rule: exactly;mso-text-raise: 11px;vertical-align: middle;">
<h3 class="size-32" lang="x-size-32" style="Margin-top: 0;Margin-bottom: 0;font-style: normal;font-weight: normal;color: #3c88e6;font-size: 28px;line-height: 36px;">
<strong>
<span style="text-decoration: inherit;color: #000000;">
Health and Longevity
</span>
</strong>
</h3>
<p class="size-17" lang="x-size-17" style="Margin-top: 12px;Margin-bottom: 0;font-size: 17px;line-height: 26px;">
This week, arguably the biggest news story in health and longevity science comes from a fascinating new study out of Emory University, which suggests that psilocybin—the active compound in “magic mushrooms”—may not only aid mental health but also slow aging and extend lifespan in mice.
</p>
<p class="size-17" lang="x-size-17" style="Margin-top: 20px;Margin-bottom: 0;font-size: 17px;line-height: 26px;">
According to researchers, psilocybin decreased oxidative stress,
preserved telomere length, and reduced DNA damage in aged mice—a rare glimpse at a potential geoprotective effect beyond the psychedelic realm.
</p>
<p class="size-17" lang="x-size-17" style="Margin-top: 20px;Margin-bottom: 20px;font-size: 17px;line-height: 26px;">
It's still early-stage (mouse models only, for now), but if replicated in humans, this could redefine how psychedelics are used in anti-aging medicine, beyond therapy into cellular rejuvenation.
</p>
</div>
</div>
<div align="center" style="font-size: 12px;font-style: normal;font-weight: normal;line-height: 19px;">
<img alt="" src="https://inboxflows.com/_/image/https%253A%252F%252Fi5.cmail19.com%252Fei%252Fd%252F18%252F4C4%252FC45%252F214458%252Fcsfinal%252FChatGPTImageJul182025at08_38_04PM-9900000000079e3c.png/?inbox_flows_img_sig=eyJwYXRoIjoiaHR0cHMlM0ElMkYlMkZpNS5jbWFpbDE5LiIsInRpbWUiOjE3NTMwMzM2MzUuODA4MDU4N30:1udY83:q398I_oZrqyzhG_id_F9OCJUvEdArFkoCDQeZ2ZNSVc" style="border: 0;display: block;height: auto;width: 100%;max-width: 900px;" width="600"/>
</div>
<div style="Margin-left: 20px;Margin-right: 20px;Margin-top: 20px;">
<div style="mso-line-height-rule: exactly;mso-text-raise: 11px;vertical-align: middle;">
<h3 class="size-17" lang="x-size-17" style="Margin-top: 0;Margin-bottom: 0;font-style: normal;font-weight: normal;color: #3c88e6;font-size: 17px;line-height: 26px;">
<span style="text-decoration: inherit;color: #000000;">
Also making waves is news that a team from UT Health San Antonio has advanced to the semifinals of the XPRIZE Healthspan competition, winning $250K for their anti-aging interventions aimed at reversing physiological decline.
</span>
</h3>
<h3 class="size-17" lang="x-size-17" style="Margin-top: 12px;Margin-bottom: 0;font-style: normal;font-weight: normal;color: #3c88e6;font-size: 17px;line-height: 26px;">
<span style="text-decoration: inherit;color: #000000;">
Their inclusion among 40 groundbreaking projects—out of 600 global entrants—highlights the growing momentum behind translational longevity research, striving not just for
longer life, but for healthier, more functional years
</span>
</h3>
<p class="size-17" lang="x-size-17" style="Margin-top: 12px;Margin-bottom: 20px;font-size: 17px;line-height: 26px;">
<span style="text-decoration: inherit;color: #000000;">
From psychedelics with potential to reignite cellular resilience to high-stakes support for holistic anti-aging innovation, these developments paint an exciting picture: longevity science is evolving fast, with practical, cutting-edge therapies nearing the clinic.
</span>
</p>
</div>
</div>
<div style="Margin-left: 20px;Margin-right: 20px;">
<div style="mso-line-height-rule: exactly;mso-text-raise: 11px;vertical-align: middle;">
<p style="Margin-top: 0;Margin-bottom: 0;">
</p>
<p class="size-32" lang="x-size-32" style="Margin-top: 20px;Margin-bottom: 20px;font-size: 28px;line-height: 36px;">
<strong>
Artificial Intelligence
</strong>
</p>
</div>
</div>
<div style="Margin-left: 20px;Margin-right: 20px;">
<div style="mso-line-height-rule: exactly;mso-text-raise: 11px;vertical-align: middle;">
<p style="Margin-top: 0;Margin-bottom: 0;">
This week in AI, Nvidia made headlines as it received clearance from the U.S. government to resume shipments of its H20 AI chips to China. These chips, slightly less powerful than Nvidia’s top-tier models, had been previously restricted due to concerns about their potential use in military or surveillance applications.
</p>
<p style="Margin-top: 20px;Margin-bottom: 20px;">
The decision to lift the ban sparked a surge in Nvidia’s stock price, reflecting market optimism about the renewed access to China’s massive AI market. Still, some lawmakers are voicing concern about national security, highlighting the ongoing tension between technological innovation and geopolitical risk.
</p>
</div>
</div>
<div align="center" style="font-size: 12px;font-style: normal;font-weight: normal;line-height: 19px;">
<img alt="" src="https://inboxflows.com/_/image/https%253A%252F%252Fi6.cmail19.com%252Fei%252Fd%252F18%252F4C4%252FC45%252F214458%252Fcsfinal%252FChatGPTImageJul182025at08_35_24PM1-9900000000079e3c.png/?inbox_flows_img_sig=eyJwYXRoIjoiaHR0cHMlM0ElMkYlMkZpNi5jbWFpbDE5LiIsInRpbWUiOjE3NTMwMzM2MzUuODA4MjIyfQ:1udY83:ZyKZliZbM6Cjrv_skHMDAakuhTyLpuSjVsk8XXotIW4" style="border: 0;display: block;height: auto;width: 100%;max-width: 900px;" width="600"/>
</div>
<div style="Margin-left: 20px;Margin-right: 20px;Margin-top: 20px;">
<div style="mso-line-height-rule: exactly;mso-text-raise: 11px;vertical-align: middle;">
<p style="Margin-top: 0;Margin-bottom: 0;">
Meanwhile, the UK government unveiled a bold £1 billion plan to supercharge its AI capabilities by expanding its national computing infrastructure. The initiative includes integrating supercomputers like Isambard-AI into a unified network designed to accelerate breakthroughs in medical research, climate modeling, and other key sectors.
</p>
<p style="Margin-top: 20px;Margin-bottom: 0;">
With ambitions to become a global leader in responsible AI development, the UK is positioning itself as a hub for cutting-edge research—reducing its dependence on private tech giants and foreign infrastructure.
</p>
<p style="Margin-top: 20px;Margin-bottom: 0;">
As countries compete for AI leadership, the race is no longer just about models and algorithms, it’s about who owns the chips, the compute, and the strategic vision to guide innovation
in the years to come.
</p>
<p style="Margin-top: 20px;Margin-bottom: 20px;">
</p>
</div>
</div>
<div style="Margin-left: 20px;Margin-right: 20px;">
<div style="mso-line-height-rule: exactly;mso-text-raise: 11px;vertical-align: middle;">
<p class="size-32" lang="x-size-32" style="Margin-top: 0;Margin-bottom: 0;font-size: 28px;line-height: 36px;">
<span style="text-decoration: inherit;color: #c8c8d4;">
05
</span>
<span style="text-decoration: inherit;color: #8c8b96;">
</span>
<span style="text-decoration: inherit;color: #000000;">
<strong>
FAQ
</strong>
</span>
</p>
<blockquote style="Margin-top: 20px;Margin-bottom: 0;Margin-left: 0;Margin-right: 0;padding-left: 14px;border-left: 4px solid #ccc;">
<p class="size-24" lang="x-size-24" style="Margin-top: 20px;Margin-bottom: 20px;font-size: 20px;line-height: 28px;">
<strong style="Margin-top: 20px;">
Is it possible to add the results of my blood lab in Gyroscope?
</strong>
</p>
</blockquote>
<p class="size-17" lang="x-size-17" style="Margin-top: 20px;Margin-bottom: 0;font-size: 17px;line-height: 26px;">
This week's FAQ comes from our member Bryce, but it gets asked a lot.
</p>
<p class="size-17" lang="x-size-17" style="Margin-top: 20px;Margin-bottom: 0;font-size: 17px;line-height: 26px;">
And the answer is... yes!
</p>
<p class="size-17" lang="x-size-17" style="Margin-top: 20px;Margin-bottom: 0;font-size: 17px;line-height: 26px;">
In your longevity coach dashboard you are able to add any blood levels manually from your trends tab.
</p>
<p class="size-17" lang="x-size-17" style="Margin-top: 20px;Margin-bottom: 0;font-size: 17px;line-height: 26px;">
Simply scroll down to "blood" and press the "+" button, then scroll down and add any information that you have available.
</p>
<p class="size-17" lang="x-size-17" style="Margin-top: 20px;Margin-bottom: 20px;font-size: 17px;line-height: 26px;">
Then you’ll be able to see these all in the same place, and they will start to also contribute to more accurate Health Score and insights.
</p>
</div>
</div>
<div align="center" style="font-size: 12px;font-style: normal;font-weight: normal;line-height: 19px;">
<img alt="" src="https://inboxflows.com/_/image/https%253A%252F%252Fi7.cmail19.com%252Fei%252Fd%252F18%252F4C4%252FC45%252F214458%252Fcsfinal%252FBloodlevel-9906db0a2805143c.png/?inbox_flows_img_sig=eyJwYXRoIjoiaHR0cHMlM0ElMkYlMkZpNy5jbWFpbDE5LiIsInRpbWUiOjE3NTMwMzM2MzUuODA4MzUwM30:1udY83:4QL6sYZ6WPdwyQgwLWbCoKLlydx15KBO35vJQJ7iTIk" style="border: 0;display: block;height: auto;width: 100%;max-width: 487px;" width="487"/>
</div>
<div style="Margin-left: 20px;Margin-right: 20px;Margin-top: 20px;">
<div style="mso-line-height-rule: exactly;mso-text-raise: 11px;vertical-align: middle;">
<p style="Margin-top: 0;Margin-bottom: 0;">
You can order your
<strong>
<a style="text-decoration: underline;transition: opacity 0.1s ease-in;color: #3175bf;">
<span style="text-decoration: inherit;color: #297bff;">
blood test directly through Gyroscope
</span>
</a>
</strong>
(only available in US and Canada) — but if you are in a different country you can also import any other lab result.
</p>
<p style="Margin-top: 20px;Margin-bottom: 0;">
Whether you test through the app or through your hospital, keeping an eye on these numbers can give an important insight into your current longevity, and help surface any issues early.
</p>
<p style="Margin-top: 20px;Margin-bottom: 20px;">
The main items to track with
<strong>
<a style="text-decoration: underline;transition: opacity 0.1s ease-in;color: #3175bf;">
<span style="text-decoration: inherit;color: #297bff;">
the longevity test are
</span>
:
</a>
</strong>
<br/>
ApoA1 · ApoB · Cortisol · DHEA-S ♂ · Estradiol ♀ · Ferritin · TSH · FSH ♀ · HbA1c · hs-CRP · HDL · Homocysteine · Insulin · LDL · Testosterone ♂ · Total Cholesterol · Triglycerides · Vitamin D
</p>
</div>
</div>
<div style="Margin-left: 20px;Margin-right: 20px;">
<div style="mso-line-height-rule: exactly;mso-text-raise: 11px;vertical-align: middle;">
<p class="size-28" lang="x-size-28" style="Margin-top: 0;Margin-bottom: 0;font-size: 24px;line-height: 32px;">
</p>
<p class="size-32" lang="x-size-32" style="Margin-top: 20px;Margin-bottom: 20px;font-size: 28px;line-height: 36px;">
<span style="text-decoration: inherit;color: #c8c8d4;">
06
</span>
<span style="text-decoration: inherit;color: #8c8b96;">
</span>
<span style="text-decoration: inherit;">
<strong>
App Update
</strong>
</span>
</p>
</div>
</div>
<div style="Margin-left: 20px;Margin-right: 20px;">
<div style="mso-line-height-rule: exactly;mso-text-raise: 11px;vertical-align: middle;">
<p class="size-20" lang="x-size-20" style="Margin-top: 0;Margin-bottom: 0;font-size: 17px;line-height: 26px;">
The new
<em>
</em>
<strong>
<a data-emb-iscopy="true" style="text-decoration: underline;transition: opacity 0.1s ease-in;color: #3175bf;">
<span style="text-decoration: inherit;color: #297bff;">
Gyroscope V8.5 update
</span>
</a>
</strong>
is now ready to download.
</p>
<p style="Margin-top: 20px;Margin-bottom: 0;">
<strong>
Now you can call your coach and have a realtime chat!
</strong>
</p>
<p style="Margin-top: 20px;Margin-bottom: 0;">
Just put on your airpods, hit "call" and start talking. (Note: headphones are
<em>
required
</em>
for the call function).
</p>
<p style="Margin-top: 20px;Margin-bottom: 20px;">
In this version, we have fixed a few of the reported bugs from last week.
You can now access it from your
<em>
coach tab
</em>
or from the bottom of the chat.
</p>
</div>
</div>
<div align="center" style="font-size: 12px;font-style: normal;font-weight: normal;line-height: 19px;">
<img alt="" src="https://inboxflows.com/_/image/https%253A%252F%252Fi8.cmail19.com%252Fei%252Fd%252F18%252F4C4%252FC45%252F214458%252Fcsfinal%252Fcoach2-9900000000079e3c.png/?inbox_flows_img_sig=eyJwYXRoIjoiaHR0cHMlM0ElMkYlMkZpOC5jbWFpbDE5LiIsInRpbWUiOjE3NTMwMzM2MzUuODA4NDY1NX0:1udY83:YN4w9XxM_hzFk7OmyxnwnvwYQDWPUexnGsK3-kQCetk" style="border: 0;display: block;height: auto;width: 100%;max-width: 900px;" width="600"/>
</div>
<div style="Margin-left: 20px;Margin-right: 20px;Margin-top: 20px;">
<div style="mso-line-height-rule: exactly;mso-text-raise: 11px;vertical-align: middle;">
<p class="size-20" lang="x-size-20" style="Margin-top: 0;Margin-bottom: 0;font-size: 17px;line-height: 26px;">
More updates in the latest app:
</p>
<p class="size-24" lang="x-size-24" style="Margin-top: 20px;Margin-bottom: 0;font-size: 20px;line-height: 28px;">
<strong>
• Strength benchmarks
</strong>
</p>
<p class="size-24" lang="x-size-24" style="Margin-top: 20px;Margin-bottom: 0;font-size: 20px;line-height: 28px;">
<strong>
• Improved coach chat
</strong>
</p>
<p class="size-24" lang="x-size-24" style="Margin-top: 20px;Margin-bottom: 20px;font-size: 20px;line-height: 28px;">
<strong>
• Updated Fat Loss Protocol
</strong>
</p>
</div>
</div>
<div style="Margin-left: 20px;Margin-right: 20px;">
<div style="mso-line-height-rule: exactly;mso-text-raise: 11px;vertical-align: middle;">
<p style="Margin-top: 0;Margin-bottom: 20px;">
And much more...
</p>
</div>
</div>
<div style="Margin-left: 20px;Margin-right: 20px;">
<div class="btn btn--flat fullwidth btn--large" style="text-align: center;">
<!--[if !mso]><!-->
<a style="border-radius: 4px;display: block;font-size: 14px;font-weight: bold;line-height: 24px;padding: 12px 24px;text-align: center;text-decoration: none !important;transition: opacity 0.1s ease-in;color: #ffffff !important;background-color: #3d63e0;font-family: sans-serif;">
Download the new app update
</a>
<!--<![endif]-->
<!--[if mso]><p style="line-height:0;margin:0;"> </p><v:roundrect xmlns:v="urn:schemas-microsoft-com:vml" href="https://camp.gyrosco.pe/t/d-l-sudiln-yultlrktit-u/" style="width:420pt" arcsize="9%" fillcolor="#3D63E0" stroke="f"><v:textbox style="mso-fit-shape-to-text:t" inset="0pt,8.25pt,0pt,8.25pt"><center style="font-size:14px;line-height:24px;color:#FFFFFF;font-family:sans-serif;font-weight:bold;mso-line-height-rule:exactly;mso-text-raise:1.5px">Download the new app update</center></v:textbox></v:roundrect><![endif]-->
</div>
</div>
</div>
<!--[if mso]></td></tr></table><![endif]-->
</div>
</div>
<div style="background-color: #ffffff;">
<div class="layout one-col stack" style="Margin: 0 auto;max-width: 600px;min-width: 320px; width: 320px;width: calc(28000% - 167400px);overflow-wrap: break-word;word-wrap: break-word;word-break: break-word;">
<div class="layout__inner" style="border-collapse: collapse;display: table;width: 100%;">
<!--[if mso]><table width="100%" cellpadding="0" cellspacing="0" role="presentation"><tr class="layout-full-width" style="background-color: #ffffff;"><td class="layout__edges"> </td><td style="width: 600px" class="w560"><![endif]-->
<div class="column" style="text-align: left;color: #000;font-size: 17px;line-height: 26px;font-family: sans-serif;">
<div style="Margin-left: 20px;Margin-right: 20px;">
<div style="mso-line-height-rule: exactly;line-height: 15px;font-size: 1px;">
</div>
</div>
</div>
<!--[if mso]></td><td class="layout__edges"> </td></tr></table><![endif]-->
</div>
</div>
</div>
<div style="background-color: #ffffff;">
<div class="layout one-col stack" style="Margin: 0 auto;max-width: 600px;min-width: 320px; width: 320px;width: calc(28000% - 167400px);overflow-wrap: break-word;word-wrap: break-word;word-break: break-word;">
<div class="layout__inner" style="border-collapse: collapse;display: table;width: 100%;">
<!--[if mso]><table width="100%" cellpadding="0" cellspacing="0" role="presentation"><tr class="layout-full-width" style="background-color: #ffffff;"><td class="layout__edges"> </td><td style="width: 600px" class="w560"><![endif]-->
<div class="column" style="text-align: left;color: #000;font-size: 17px;line-height: 26px;font-family: sans-serif;">
<div style="Margin-left: 20px;Margin-right: 20px;">
<div style="mso-line-height-rule: exactly;mso-text-raise: 11px;vertical-align: middle;">
<p style="Margin-top: 0;Margin-bottom: 0;">
</p>
<p class="size-20" lang="x-size-20" style="Margin-top: 20px;Margin-bottom: 0;font-size: 17px;line-height: 26px;">
That’s all for this week’s newsletter.
</p>
<p class="size-20" lang="x-size-20" style="Margin-top: 20px;Margin-bottom: 0;font-size: 17px;line-height: 26px;">
<strong>
Thanks for being an early Gyroscope member!
</strong>
</p>
<p style="Margin-top: 20px;Margin-bottom: 0;">
</p>
</div>
</div>
</div>
<!--[if mso]></td><td class="layout__edges"> </td></tr></table><![endif]-->
</div>
</div>
</div>
<div style="background-color: #000000;background: 0% 0%/auto auto no-repeat url(https://inboxflows.com/_/image/https%253A%252F%252Fi2.cmail19.com%252Fei%252Fd%252F18%252F4C4%252FC45%252F214458%252Fcsfinal%252Fbg51.jpg/?inbox_flows_img_sig=eyJwYXRoIjoiaHR0cHMlM0ElMkYlMkZpMi5jbWFpbDE5LiIsInRpbWUiOjE3NTMwMzM2MzUuNzg5OTA0OH0:1udY83:k6qDjfgl1WhtbFro8d3w0coQ0nFA0I9LyBQERZhkPFU) #000000;background-position: 0% 0%;background-image: url(https://inboxflows.com/_/image/https%253A%252F%252Fi2.cmail19.com%252Fei%252Fd%252F18%252F4C4%252FC45%252F214458%252Fcsfinal%252Fbg51.jpg/?inbox_flows_img_sig=eyJwYXRoIjoiaHR0cHMlM0ElMkYlMkZpMi5jbWFpbDE5LiIsInRpbWUiOjE3NTMwMzM2MzUuNzg5OTA0OH0:1udY83:k6qDjfgl1WhtbFro8d3w0coQ0nFA0I9LyBQERZhkPFU);background-repeat: no-repeat;background-size: auto auto;">
<div class="layout one-col stack" style="Margin: 0 auto;max-width: 600px;min-width: 320px; width: 320px;width: calc(28000% - 167400px);overflow-wrap: break-word;word-wrap: break-word;word-break: break-word;">
<div class="layout__inner" style="border-collapse: collapse;display: table;width: 100%;">
<!--[if mso]><table width="100%" cellpadding="0" cellspacing="0" role="presentation"><tr class="layout-full-width" style="background: 0% 0%/auto auto no-repeat url(https://inboxflows.com/_/image/https%253A%252F%252Fi2.cmail19.com%252Fei%252Fd%252F18%252F4C4%252FC45%252F214458%252Fcsfinal%252Fbg51.jpg/?inbox_flows_img_sig=eyJwYXRoIjoiaHR0cHMlM0ElMkYlMkZpMi5jbWFpbDE5LiIsInRpbWUiOjE3NTMwMzM2MzUuNzg5OTA0OH0:1udY83:k6qDjfgl1WhtbFro8d3w0coQ0nFA0I9LyBQERZhkPFU) #000000;background-position: 0% 0%;background-image: url(https://inboxflows.com/_/image/https%253A%252F%252Fi2.cmail19.com%252Fei%252Fd%252F18%252F4C4%252FC45%252F214458%252Fcsfinal%252Fbg51.jpg/?inbox_flows_img_sig=eyJwYXRoIjoiaHR0cHMlM0ElMkYlMkZpMi5jbWFpbDE5LiIsInRpbWUiOjE3NTMwMzM2MzUuNzg5OTA0OH0:1udY83:k6qDjfgl1WhtbFro8d3w0coQ0nFA0I9LyBQERZhkPFU);background-repeat: no-repeat;background-size: auto auto;background-color: #000000;"><td class="layout__edges"> </td><td style="width: 600px" class="w560"><![endif]-->
<div class="column" style="text-align: left;color: #000;font-size: 17px;line-height: 26px;font-family: sans-serif;">
<div style="Margin-left: 20px;Margin-right: 20px;">
<div style="mso-line-height-rule: exactly;line-height: 112px;font-size: 1px;">
</div>
</div>
</div>
<!--[if mso]></td><td class="layout__edges"> </td></tr></table><![endif]-->
</div>
</div>
</div>
<div style="background-color: #000000;">
<div class="layout one-col stack" style="Margin: 0 auto;max-width: 600px;min-width: 320px; width: 320px;width: calc(28000% - 167400px);overflow-wrap: break-word;word-wrap: break-word;word-break: break-word;">
<div class="layout__inner" style="border-collapse: collapse;display: table;width: 100%;">
<!--[if mso]><table width="100%" cellpadding="0" cellspacing="0" role="presentation"><tr class="layout-full-width" style="background-color: #000000;"><td class="layout__edges"> </td><td style="width: 600px" class="w560"><![endif]-->
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🗞️ Gyroscope Newsletter: Why calorie deficits “don’t work”, the latest AI news, and more...
The Gyroscope Newsletter 01 EssayWhy Calorie Deficits "Don't Work"“I’m eating in a calorie defici...